Topical Vitamin B3 Reduces Skin Cancer Risk

Research has shown that vitamin B3 lowers the risk of developing nonmelanoma skin cancers. Additionally, exciting new studies are finding that topical vitamin B3 works the same as oral supplements at reducing the rates of new skin cancers, as well as premalignant actinic keratosis. For those seeking an excellent choice for a topical vitamin B3 cream, look no further than Cloud Vitamin Cream. Daily application of Clouds’s Vitamin B3 cream provides an RDA’s worth of vitamin B3.

First, let’s discuss the various types of skin cancer. There two primary types of skin cancer:  melanoma and nonmelanoma. According to the Canadian Dermatology Association, “Melanoma is a less common but most dangerous form of skin cancer. It starts in the melanocytes or pigment producing cells found in the outer layer of the skin. These cells grow out of control and form a tumour. Melanomas are often brown and black in colour but can show other shades.” 

Nonmelanomas are classified as basal cell carcinomas (BCCs) or squamous cell carcinomas (SCCs). The American Academy of Dermatology (AAD) defines a basal cell carcinoma as, “This skin cancer usually develops on skin that gets sun exposure, such as on the head, neck, and back of the hands. BCC is especially common on the face, often forming on the nose. It is possible to get BCC on any part of the body, including the trunk, legs, and arms.” Basal cell carcinomas are slow growing and rarely metastasize. Regarding squamous cell carcinomas, the AAD states that, “This skin cancer tends to develop on skin that has been exposed to the sun for years. It is most frequently seen on sun-exposed areas, such as the head, neck, and back of the hands. Women frequently get SCC on their lower legs. It is possible to get SCC on any part of the body, including the inside of the mouth, lips, and genitals.” SCCs can spread to other parts of the body. 

Lastly, there is also a type of precancer known as actinic keratoses or AKs. The Skin Cancer Foundation indicates that, “Actinic keratoses (AK), also called solar keratoses, are scaly, crusty growths (lesions) caused by damage from the sun’s ultraviolet (UV) rays. They typically appear on sun-exposed areas such as the face, bald scalp, lips, and the back of the hands, and are often elevated, rough in texture, and resemble warts.  Most become red, but some will be tan, pink, and/or flesh-toned. If left untreated, up to ten percent of AKs develop into squamous cell carcinoma (SCC), the second most common form of skin cancer. In rarer instances, AKs may also turn into basal cell carcinomas, the most common form of skin cancer.”

Though skin cancer is treatable, prevention is the best way to protect yourself. According to a study published in the October 2015 issue of “The New England Journal of Medicine”, new trials have found that vitamin B3 is effective at preventing the development of skin cancer. The study found that, “Nonmelanoma skin cancers, such as basal cell carcinoma and squamous cell carcinoma, are common cancers that are caused principally by UV radiation. Nicotinomide (vitamin B3) has been shown to have protective effects against damage caused by UV radiation and to reduce the rate of new premalignant actinic keratoses.” This is very significant, because vitamin B3 is widely available, affordable and easy to use. The study went on to add that, “At 12 months, the rate of new nonmelanoma skin cancers was lower by 23% in the nicotinamide group than in the placebo group.”

Vitamin B3 can be obtained through oral supplements or topical creams. The efficacy of both is very similar. Research published in a recent issue of the “British Journal of Medicine” found that, “topical and oral nicotinamide reduced this immunosuppression by 59% and 66%, respectively.” The study concluded that, “In healthy in vivo human skin, topical and oral nicotinamide substantially reduced the suppressive effects of MAL-PDT on delayed-type hypersensitivity responses.” This is very important to note. For patients that wish to reduce their risk of developing skin cancer, having a choice about whether to supplement with oral vitamins or topical creams is considerable. Some patients cannot swallow oral supplements, don’t want to take more pills, or simply want the ease of a topical cream. With this new research, patients can choose a topical vitamin B3 cream and have the confidence that it will deliver results. 

We are all striving to lead healthy lifestyles and maintain the health of our skin. Studies regarding the efficacy of vitamin B3 continue to prove that it has the ability to reduce the rate of new nonmelanoma skin cancers. Even more exciting is the research that shows that topical vitamin B3 cream is a reliable alternative compared to oral supplements. Daily application of Cloud’s Vitamin B3 Cream gives you the opportunity to increase your protection against nonmelanoma skin cancers with a safe, effective topical cream. 



  • Canadian Dermatology Association, 
  • American Academy of Dermatology, 
  • The Skin Cancer Foundation, 
  • “A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention”, by Andrew C. Chen, M.B., B.S., Andrew J. Martin, Ph.D., Bonita Choy, M.Med., Pablo Fernández-Peñas, Ph.D., Robyn A. Dalziell, Ph.D., Catriona A. McKenzie, M.B., B.S., Richard A. Scolyer, M.D., Haryana M. Dhillon, Ph.D., Janette L. Vardy, M.D., Anne Kricker, Ph.D., Gayathri St. George, M.Sc.Med., Niranthari Chinniah, M.B., B.S., Gary M. Halliday, D.Sc., and Diona L. Damian, Ph.D., The New England Journal of Medicine, October 29, 2015.
  • “Nicotinamide reduces photdynamic therapy-induced immunosuppression in humans”, by S.M. Thanos, G.M. Halliday and D.L. Damian, British Journal of Dermatology, September 2012.
November 30, 2015 by Cathy Mohr
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