Recent studies have found that vitamin B3, also known as nicotinomide or niacinamide, is a key ingredient for skin cancer prevention. Nicotinomide does this by preventing immunosuppression caused by sun exposure, specifically UVB and longwave UVA rays. Combining the use of sunscreen and topical vitamin B3 is imperative for total sun protection, as sunscreen alone is not able to filter longwave UVA rays. Cloud’s Vitamin B3 cream has 4% niacinamide, which is the maximum physiological strength. Applying Vitamin B3 cream daily under your sunscreen will provide protection against the sun’s rays and prevent the suppression of the immune system that can lead to carcinogenesis, or the formation of skin cancer.
Let’s take a moment to discuss immunosuppression and how it relates to skin cancer. When the immune system is functioning properly, it acts as a defender that stops potentially cancerous cells from developing into tumors. Immunosuppression is defined as something that reduces the effectiveness of the immune system, which can cause the body to be susceptible to malignancies, specifically skin cancers. Some causes of immunosuppression are aging, malnutrition and certain diseases, like HIV and leukemia. Sometimes immunosuppression is achieved deliberately, as in the case of an organ transplant patient. In this instance, the patient is given immunosuppressive drugs to increase the chance that the body will accept the organ. However, immunosuppression can also be caused by something we are all exposed to regularly: the sun.
An article in the “British Journal of Dermatology”, titled, “Topical nicotinomide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humans” illustrates how the sun has a direct effect on the impairment of the body’s immune system. The article stated that, “Longwave UVA, which is poorly filtered by most sunscreens, was highly immune suppressive even at doses equivalent to 20 minutes of sun exposure.” The article also discussed how vitamin B3 works to prevent a suppressed immune system adding that, “In the single irradiation study, we showed that one application of nicotinomide was sufficient to halve the level of observed immunosuppression.” This makes it clear that sunscreen alone, though it prevents sunburn, is not enough to completely protect the body from all the sun’s rays. Adding a topical agent with vitamin B3, or nicotinomide, is an essential step for full spectrum protection and the prevention of skin cancer.
“The Journal of Nucleic Acids” published a review article which also illustrates that nicotinomide plays a vital role in the prevention of skin cancer formation. The article called, “Role of Nicotinomide in DNA Damage, Mutagenesis, and DNA Repair” agreed that, “Both UVB (290 – 320 nm) and UVA (320 – 400 nm) in sunlight are immune suppressive.” The study also found nicotinomide to reduce the occurrence of immunosuppression, indicating that, “Topical nicotinomide also slowed down the rate of skin tumor development. It was also suggested that protection from immunosuppression is a mechanism by which nicotinomide and niacin prevent UV-induced carcinogenesis.” The study concluded that, “we have shown that nicotinomide protects from UV-induced immunosuppression in humans.” These findings are exciting because we all want to lead active lives and enjoy being outside while maintaining healthy skin. Therefore, by simply adding topical vitamin B3, we can boost immune system function and inhibit the development of skin cancer.
With these study findings in mind, it is clear that vitamin B3 is an essential ingredient for the preservation and maintenance of skin health. Daily application of your favorite sunscreen paired with Cloud’s Vitamin B3 cream is a winning combination that gives the skin true full spectrum protection and works to prevent immunosuppression that can lead to skin cancer.
- “British Journal of Dermatology”, 2009, 161, pp 1357 – 1364, “Topical nicotinomide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humans”, by G. Sivapirabu, E. Yiasemides, G. M. Halliday, J. Park and D. L. Damian.
- “Journal of Nucleic Acids”, June 2010, Volume 2010, Article ID 157591, 13 pages, “Role of Nicotinomide in DNA Damage, Mutagenesis, and DNA Repair” by Devita Surjana, Gary M. Halliday and Diona L. Damian.